Hoffenheim begin their first ever UEFA Champions League campaign at Shakhtar Donetsk in Group F. Shakhtar won all of their games at Metalist Stadium in last year's competition.
QPR take on Millwall at Loftus Road in the Sky Bet Championship. The last three meetings between the sides on this ground have ended all square.
Jose Mourinho's Manchester United side travel to Switzerland to face Young Boys in the Stade de Suisse.
Pep Guardiola's Manchester City side host French side Lyon at the Etihad Stadium in their opening UEFA Champions League match of the season.